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MAPK (p44) ERK1 Antibody

Catalog # Pack Size Price(USD)
ICP9810 100 µg $295.00

Quantity:

Product Description
Affinity purified rabbit polyclonal p44 MAPK antibody is developed using the C-terminal peptide of human MAPK (ERK1).
 
Western blot analysis of mouse brain extract (B) and spleen extract (A) with ICP9810.
Species
Rabbit
Formulation
250 µg/mL in TBS, 50% glycerol, 0.01% NaN3
Immunogen
Human p44 ERK1 C-terminal peptide-KLH conjugates
Purification
The antibody was affinity purified with the p44 ERK1 C-terminal peptide on agarose.
Specificity
The antibody recognizes p44 ERK1 of human, rat, bovine, mouse and rabbit. There is a slight cross reaction with p42 ERK2.
Applications
ELISA; WB; IP
Scientific Description
One of the members of mitogen-activated protein kinases is called P44 MAP Kinase (Erk1). It participates in cell growth and differentiation. [1,2] By phosphorylating transcription factors, (e., ELK-1), P44 MAP kinase regulates meiosis and mitosis of the cell. In the case of human MAP kinase, Erk1 activates Elk-1 through phosphorylation of threonine 202 and tyrosine 204. It is also known that Erk1 autophosphorylates tyrosine. [3]
Storage & Stability
Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is three years from date of shipping if stored properly.

Product Specific References

1. Mol Cell Biol. 1993.13: 4679–4690. doi:10.1128/MCB.13.8.4679
2. Cell. 1995. 80: 179–185. doi:10.1016/0092-8674(95)90401-8
3. EMBO J. 1991. 10: 885–892.