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P70 S6K Antibody

Catalog # Pack Size Price(USD)
ICP9830 100 µg $295.00

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Product Description
p70 S6K is a ribosome S6 kinase. Affinity purified rabbit polyclonal anti-p70 S6K is developed using a C-terminal peptide based on human p70 S6K (C-ISKRPEHLRMNL).
 
Western blot analysis of p70 S6K immunoprecipitated from mouse brain extract (B) and using S6K-HRP as a probe. Immunoprecipitation negative control (A).
Species
Rabbit
Formulation
250 µg/mL in TBS, 0.01% NaN3
Immunogen
Human p70 S6K C-terminal peptide (ISKRPEHLRMNL)-KLH conjugates
Purification
The antibody was affinity purified with peptide (ISKRPEHLRMNL) on agarose.
Specificity
Recognizes p70 S6K of human, mouse, and rat.
Applications
ELISA; WB; IP
Scientific Description
p70 S6K is a protein serine/threonine kinase that exists ubiquitously. [1] p70 S6K affects the activities of the cell cycle. p70 S6K is an important regulator of cell proliferation. [2] p70 S6K activation requires sequential phosphorylation at proline-directed residues in the putative auto-inhibitory pseudo-substrate domain, as well as threonine 389. Activation of p70 S6K requires phosphoinositide 3-kinase (PI3-K)-dependent signal(s).
Storage & Stability
Product is stable for several weeks at 4°C. For extended storage,  store product at -20°C. Expiration date is three years from date of shipping if stored properly.

Product Specific References

1. Crit. Rev. Biochem. Mol. Biol. 1994. 29(6): 385-413.
doi:10.3109/10409239409083485

2. J. Biol. Chem. 1996. 271(2): 963-971. doi:10.1074/jbc.271.2.963

3. Mol. Cell Biol. 1999. 19(4): 2921-2928.