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p42 MAPK (ERK2) Antibody

Catalog # Pack Size Price(USD)
ICP0205 100 μg $295.00


Product Description
Affinity purified rabbit polyclonal anti-p42 MAPK antibodies are developed with the C-terminal peptide of human MAPK (ERK2).  
Western blot analysis of mouse brain and spleen samples immunoprecipitated with anti-ERK2 antibody: left two lanes with ERK 2 and right two lanes with pre-immune serum.
250 µg/mL in TBS, 50% glycerol, 0.01% NaN3
Human p42 ERK2 C-terminal peptide-KLH conjugates
The antibody is affinity purified with the p42 ERK2 C-terminal peptide on agarose.
The antibody recognizes human, rat, bovine, mouse and rabbit p42 ERK2. It does not cross-react with p44 ERK1.
Scientific Description
Maturation of mitogen-activated protein kinase (MAPK), also known as extracellular signal regulated kinase 2 (ERK2), is involved in the eukaryotic signalling process. [1] It is activated by a dual phosphorylation on threonine and tyrosine residues by the dual-specificity kinase MKK1/2. After stimulation, ERK2 p42 translocates to the nucleus. [2] Once phosphorylated, ERK2 can form dimers with phosphorylated and unphosphorylated ERK2 partners. ERK2 can also phosphorylate many substrates, for instance EGFR, c-PLA2, Elk1/TCF and c-Myc. [3-5]
Storage & Stability
Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.

Product Specific References

1. Mol. Cell Biol. 1992. 12: 915–927. doi:10.1128/MCB.12.3.915
2. J. Biol. Chem. 1991. 266(23): 15266–15276.      
3. Cell. 1993. 72: 269–278. doi:10.1016/0092-864(93)90666-E
4. J. Biol. Chem. 1992. 267(34): 24796-24804.