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p53 Antibody

Catalog # Pack Size Price(USD)
ICP7110 100 μg $295.00

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Product Description
These antibodies were developed based on human p53 sequences (25-40 aa). It was tested to detect human p53 in human cell and tissue.
 
Western blot analysis of p53 in HeLa cell lysates with p53 antibody (ICP7110)                    A: 15 µg/mL crude protein      B: 45 µg/mL crude protein
Species
Rabbit
Formulation
250 µg/mL in PBS, pH 7, with 50 % glycerol
Immunogen
Human phosphor p53 peptide (15-40 aa) KLH conjugates
Purification
Peptide-affinity chromatography
Specificity
The antibody recognizes human p53 in cell and tissue.
Species   Tested
Mouse and human
Applications
ELISA (1:2500); WB (1:2500)
Scientific Description
P53 (tumour protein 53 or TP53) regulates the cell cycle by acting as a transcription factor. It suppresses tumours and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman". This refers to its role in conserving stability by preventing genome mutation. P53 refers to its molecular mass (53 kDa) on SDS-PAGE.
Storage & Stability
Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.
Product Specific References
1. Strachan T. et al. Human Molecular Genetics 2. Ch. 18, 1999 Cancer Genetics.