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Description: Affinity purified rabbit polyclonal anti-p44 MAPK antibody is developed with c-terminal peptide of human MAPK (ERK1). |
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Species: Bovine
Formulation: 250 µg/mL in TBS, 50% Glycerol, 0.01% NaN3.
Storage & Stability: Store product at –20 0C. Three years from date of shipping
Immunogen: human p44 ERK1 c-terminal peptide-KLH conjugate
Purification: The antibody is affinity purified with p44 ERK1 c-terminal peptide-on agarose
Specificity: The antibody is recognizes p44 ERK1 of human, rat, bovine, mouse, and rabbit. There is slight cross-reaction with p42 ERK2
Application(s): ELISA, WB, IP
Scientific Description:
One of the members of mitogen-activated protein kinases is called p44 MAP Kinase (Erk1). It participates in cell growth and differentiation. [1,2] By phosphorylating the transcription factors (e., ELK-1), p44 MAP kinase (Erk1) regulates meiosis as well as mitosis of the cell. In the case of human MAP kinase, Erk1 activates Elk-1 through phosphorylation of threonine 202 and tyrosine 204. It is also known that Erk1 autophosphorylates tyrosine. [3]
References: 1. Charest, D.L, et al. Mol Cell Biol. 1993, 13, 4679–4690.
2. Marshall, C.J. Cell 1995, 80, 179–185.
3. Payne, D.M., et al. EMBO J. 1991, 10, 885–892.
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mTOR (n-terminal) Antibody
