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Competitive Inhibitor of the Methyl Lysine Antibody (ICP0504) |
| Catalog Number |
Pack Size |
Price (US) |
| ICP0504-5000 |
5mg |
$150 |
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Description: This product is the BSA with the trimethylated lysine residues. The signal of proteins with trimethylated lysine can be competitively inhibited by 50 ug/mL of this conjugates. There is no inhibition when this inhibitor is used in the presence of 3% of BSA. |
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Species:
Formulation: 2 mg/mL in PBS, 50% glycerol.
Storage & Stability: Store product at –20 0C. One year from date of shipping.
Application(s): Specific Inhibition Study: 50 µg/ml. or 1:40
Scientific Description: MeK is a conserved post-translational modification and is an important biochemical process for many protein-protein interactions. It is found in many proteins for example calmodulin, cytochrome C, chromosomal proteins, histones, non-histones as well as neural storage body proteins. It has been suggested that methylation of lysine plays an important role in gene silencing.[1-3]
References: 1. Im, H. et al. J. Biol. Chem. 2003, 278, 18346-18352.
2. Ng, H. H. et al. J. Biol. Chem. 2002, 277, 34655-34657.
3. Zegerman, P. et al. J. Biol. Chem. 2002, 277, 11621-11624.
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