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Description: p70 S6K is a ribosome s6 kinase. Affinity purified rabbit polyclonal anti-p70 S6K is developed with C-terminal peptide based on human p70 S6K (C-ISKRPEHLRMNL).
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Species: Rabbit
Formulation: 250 µ:g/mL in TBS, 0.01% NaN3.
Storage & Stability: Store product at –20oC. Three years from date of shipping
Immunogen: human p70 S6K c-terminal peptide (ISKRPEHLRMNL)-KLH conjugates
Purification: Affinity purified with peptide (ISKRPEHLRMNL) on agarose.
Specificity: Recognize p70 S6K of human, mouse, rat
Applications: ELISA, WB, IP
Scientific Description: p70S6K is a protein serine/threonine kinase that exists ubiquitously. [1] p70S6K affects the activities of cell cycle. p70S6K is an important regulator of cell proliferation. [2] p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389. Activation of p70S6K requires a phosphoinositide 3-kinase (PI3-K)-dependent signal(s).
References: 1. Ferrari, S. et al. Crit. Rev. Biochem. Mol. Biol. 1994, 29, 6, 385-413. Review.
2. Edelmann, H. M. et al. J. Biol. Chem. 1996, 271, 2,
963-971.
3. Romanelli, A et al. (1999) Mol. Cell Biol. 1999, 19, 4, 2921-2928.
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mTOR (n-terminal) Antibody
